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Guangxi Sciences. 2015, (01)

Effect of Heparanase on Lymphatic Metastasis of Papillary Thyroid NeoplasmsChinese Full Text

YANG Chuan-jia;GONG Jian;WU Feng;WANG Guo-feng;XU Wei-xue;LIU Zhen;CUI Dong-xu;Department of Pancreatic and Thyroid,Shengjing Hospital,China Medical University;Department of Clinical Pharmacy,School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University;Intensive Care Unit,Sixth Hospital of Dalian;Department of Cardiology,the Fourth Hospital,China Medical University;

Abstract: 【Objective】By studying the relationship between heparanase（HPA）content and micro-lymphatic vessel density,we investigated the effect of heparanase on lymphatic metastasis of papillary thyroid cancer.【Methods】Heparanase and D2-40 levels were detected in 150 specimens of papillary thyroid cancer and 200 of nodular goiter by Envision immunohistochemistry.Micro-lymphatic vessels were identified immunohistochemically as D2-40-positive.The relationship between micro-lymphatic vessel density and heparanase levels was analyzed.【Results】Micro-lymphatic vessel density and heparanase levels in patients with papillary thyroid cancer were significantly higher than those in nodular goiter patients（P ＜0.01）.The content of heparanase was positively related with the micro-lymphatic vessel density in tumor tissues（P＜0.01）.【Conclusion】The metastasis process of papillary thyroid cancer is associated with heparanase levels.Heparanase may be a potential marker on the therapeutic effect and new drugs for papillary thyroid cancer in the future.
Keywords：

thyroid carcinoma; lymph node metastasis; micro-lymphatic vessel; heparanase;

  • DOI：

    10.13656/j.cnki.gxkx.20140610.002

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  • Classification Code：

    R736.1

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