Study the Effect of Tigogenine on Hemorheological Abnormality in Rats with Acute Blood StasisChinese Full Text
YUAN Zhi-lin;LI Yan-jing;ZHONG Zheng-xian;CHEN Xue-fen;Guangxi Institute of Chinese Traditional Medical and Pharmaceutical Science;Guangxi Key Laboratory of Traditonal Chinese Medicine Quality Stardands;
Abstract: 【Objective】The effect of tigogenine on hemorheological abnormality was evaluated in the rats with acute blood stasis.【Methods】The model of acute blood stasis in rats was made by subcutaneously injecting amount of epinephrine and ice water simulation,in whic the changes of hemorheologic indexes were observed after giving different doses of tigogenine.【Results】The viscosity of whole blood（BV）and plasma（PV）in the rats of acute blood stasis model were significantly higher than those in the normal group（P＜0.01）.The tigogenine reduced the viscosity of whole blood and plasm,erythrocyte aggregation（EAI）,the hematocrit（HCT）,deformed index（DI）,electrophoresis time（ET）,erythrocyte sedimentation rate（ESR）and so on.Also,the content of fibrinogen（Fib）was increased while prothrombin time（PT）,activated partiac thrombin time（APTT）and thrombin time（TT）were shortened.【Conclusion】Tigogenine can improve the hemorheological abnormality in rats with acute blood stasis.
- DOI：
10.13656/j.cnki.gxkx.20140504.012
- Series：
- Subject：
- Classification Code：
R285.5
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