Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size
Colin M. Carpenter, Brian W. Pogue, Shudong Jiang, Hamid Dehghani, Xin Wang, Keith D. Paulsen, Wendy A. Wells, Jorge Forero, Christine Kogel, John B. Weaver, Steven P. Poplack, and Peter A. Kaufman
Keywords (OCIS):
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
Abstract
A multimodality instrument that integrated optical or near-infrared spectroscopy into a magnetic resonance imaging (MRI) breast coil was used to perform a pilot study of image-guided spectroscopy on cancerous breast tissue. These results are believed to be the first multiwavelength spectroscopic images of breast cancer using MRI-guided constraints, and they show the cancer tumor to have high hemoglobin and water values, decreased oxygen saturation, and increased subcellular granularity. The use of frequency-domain diffuse tomography methods at many wavelengths provides the spectroscopy required for recovering maps of absorbers and scattering spectra, but the integration with MRI allows these data to be recovered on an image field that preserves high resolution and fuses the two data sets together. Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography.
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Virtual Issues
Vol. 2, Iss. 5 Virtual Journal for Biomedical Optics
History
Original Manuscript: December 19, 2006
Manuscript Accepted: January 9, 2007
Published: March 19, 2007
Citation
C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size," Opt. Lett. 32, 933-935 (2007)
http://www.opticsinfobase.org/abstract.cfm?URI=ol-32-8-933
DOI
doi:10.1364/OL.32.000933
References
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