Abnormal intracellular calcium channel in rat with chronic heart failureChinese Full Text

GONG Jingmei;SUN Xuelin;ZHOU Yongzhong;HU Shuting;Cardiovascular Medicine,the Second Affiliated Hospital of Ningxia Medical University;Obstetrics and Gynecology,Zhongwei people’s Hospital;Experimental Center,School of Basic Medicine,Ningxia Medical University;Department of Physiology,School of Basic Medicine,Ningxia Medical University;

Abstract: Objective To study the abnormal intracellular calcium channel in rat with chronic heart failure（HF）.Methods Theadult male SD rats were randomized to receive either myocardial infarction（MI） or a sham procedure. The cytosolic caffeine- induced Ca2 +transients were investigated and the expression of ryanodine receptor（RyR2） and FKBP12. 6 were assessed by using laser scanning confocal microscope and Western- blot. Results The cytosolic Ca2 +transients were markedly reduced in amplitude in HF myocytes（ΔF /F0= 12. 8 ± 1. 2） compared with control myocytes（ ΔF /F0= 32. 8 ± 1. 6,P ＜ 0. 05）,and the expression of FKBP12. 6 was significantly reduced in HF rat. Conclusion Diastolic sarcoplasmic reticulum Ca2 +leak（ due to down- regulation of FKBP12. 6） may contribute to HF.

Keywords：

Heart failure; Sarcoplasmic reticulum; Ca2+ transient; Ryanodine receptor; FK506 biding protein;

DOI：
10.13621/j.1001-5949.2014.10.0865
Series：
Subject：
Classification Code：
R541.6

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