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Study on the anti-inflammatory active components and mechanism of Polygonati-rhizoma based on network pharmacologyChinese Full Text

XU Hui;DAI Lei;DENG Pengfei;XU Xiaoniu;School of Forestry and Landscape Architecture, Anhui Agricultural University;

Abstract: Polygonati rhizoma has important medicinal and edible values, tastes sweet and refreshing. To explore the possible anti-inflammatory active components and mechanism of Polygonati rhizoma, the active components in Polygonati rhizoma were screened by TCMSP database; the target genes related to Polygonati rhizoma active components were found in Pharmmapper and Uni Prot database, human inflammatory related genes were screened using GeneCards and Malacards databases, and the potential anti-inflammatory targets of Polygonati rhizoma were obtained by intersection; GO enrichment and KEGG pathway annotation were carried out by Metascape database; the "Compound-Target-Disease" network diagram of potential anti-inflammatory targets of Polygonati rhizoma was constructed by using Cytoscape3.6.1 software, and PPI network diagram was constructed by using string database. A total of 12 potential active components, including(+)-Syringaresinol-O-beta-D-glucoside, zhonghualiaoine 1, Diosgenin, 3’-Methoxydaidzein, Beta-Sitosterol, Methylprotodioscin and 65 potential anti-inflammatory targets of Polygonati rhizoma, such as ALB, EGFR, MAPK1, CASP3, ESR1, etc., were screened out, and 46 GO items and 13 KEGG items were screened out in bioinformatics enrichment analysis. The pathways mainly involve in cancer, prostate cancer, IL-17 signaling pathway and hepatitis B. The study reveals the mechanism of anti-inflammatory multi-component, multi-target and multi-channel of Polygonati rhizoma, which provides a basis for the research of anti-inflammatory mechanism of Polygonati rhizoma and the subsequent experimental research.
  • DOI:

    10.13610/j.cnki.1672-352x.20220325.020

  • Series:

    (D) Agriculture; (E) Medicine & Public Health

  • Subject:

    Traditional Chinese Medicinal Herbs

  • Classification Code:

    R285

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