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Journal of Chinese Practical Diagnosis and Therapy. 2014, (11)

Influence of pre-and post-incisional administration of flurbiprofen axetil on sufentanil consumption in patient-controlled intravenous analgesia after colorectal carcinoma surgeryChinese Full Text

ZHANG Rui-qin;LIN Xue;CHANG Pan;PAN Hong;LI Di;LIU Ming-yuan;WANG Wei-na;Department of Anesthesiology,the Second Affiliated Hospital of Harbin Medical University,the Key Laboratory of Anesthesiology and Critical Care Medicine;

Abstract: Objective To investigate the effect of pre-and post-incisional administration of flurbiprofen axetil（FA）in patient-controlled intravenous analgesia（PCIA）after colorectal surgery,and its influence on sufentanil consumption.Methods Forty patients undergoing elective colorectal carcinoma resection under inhalational-intravenous general anesthesia were divided into observation group and control group,with 20 patients in each group.Observation group was intravenously injected 100 mg FA 30 minutes before skin incision,and control group was intravenously injected 100 mg FA 30 minutes after skin incision.Both two groups received postoperative PCIA with sufentanil 0.04μg/（kg·h）dilated into normal saline 150 mL.Analgesic and sedative efficacy was evaluated at the time points of 0,2,4,6and 24 hours after operation by recording visual analogue scale（VAS）,Bruggrmann comfort scale（BCS）,the time to the first PCIA trigger,the actual number to press PCIA trigger within 24 hours,the cumulative doses of SF consumption within 6and24 hours and the incidence of adverse reactions.Results VAS and BCS at the time points of 0,2,4,6and 24 hours postoperatively were not significantly different between two groups（P＞0.05）.In observation group,the time to the first PCIA trigger（（52.50±7.67）minutes）,sufentanil consumption at the time points of 6and 24 hours postoperatively（（24.60±6.31）,（79.32±12.72）μg）,and the actual number to press PCIA trigger during postoperative 24hours（（6.67±2.40）times）were significantly different from those in control group（（57.80±6.30）minutes,（28.32±4.85）μg,（88.68±14.90）μg,（8.75±2.38）times）（P＜0.05）.There was no significant difference in the incidence of adverse reactions within 24 hours postoperatively between observation group（10%）and control group（15%）（P＞0.05）.Conclusion Intravenous injection of FA 100 mg 30 minutes before incision plus postoperative PCIA with sufentanil can enhance postoperative analgesic effects and reduce SF consumption in patients undergoing colorectal carcinoma resection.
Keywords：

Colorectal carcinoma; resection; flurbiprofen axetil; sufentanil; analgesia;

  • DOI：

    10.13507/j.issn.1674-3474.2014.11.034

  • Series：

  • Subject：

  • Classification Code：

    R614;R735.34

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