Study of the Dose-effect Relationship of γ-H2AX RadiationChinese Full Text
CUI Shuang-shuang,FAN Ya-guang,SUN Zhi-juan,et al.Institnte of Radiation Medicina,Chinese of Medical Sciences and Peking Union Medical College,Tianjing 300192 China
Abstract: Objective By using laser scanning confocal microscopy（LSCM）to test the dose-effects relationship between ionizing radiation intensity and quantity of the γ-H2AX in vivo and in vitro respectively,and the consistency relationship between the vivo and vitro retrial.Methods To irradiate the peripheral blood from Wister female rats by 137Cs at 7 with different doses（0、0.5、1、2、2.54、4、6、8Gy）extract the lymphocytes from the peripheral blood and detect the dose-effects relationship between irradiation intensity and number of γ-H2AX foci.Results There are good dose-effects relationships between the irradiation and foci number both in vivo and in vitro,which are linear,Yvivo=0.096+0.13X;Yvitro=0.040+0.21X.And there is good consistency（R=0.98）between the γ-H2AX in vivo and in vitro.Conclusions γ-H2AX has the possibility for clinical trial as an indicator,and we can use vitro trials in place of the vivo trails to evaluate the dose people received.
- DOI：
10.13491/j.cnki.issn.1004-714x.2010.01.038
- Series：
- Subject：
- Classification Code：
R144.1
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