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Journal of Jilin University(Medicine Edition). 2014, (05) Core

Correlation between CHI3L1 polymorphism and serum YKL-40 and bronchial asthmaChinese Full Text

CHEN Min;LAI Tian-wen;ZHAO Xuan-na;LYU Ying-ying;GAO Zheng-ni;HUANG Dan;LIU Sheng-ming;Department of Respiratory Medicine,First Affiliated Hospital,Jinan University;Department of Respiratory Medicine,Affiliated Hospital,Guangdong Medical College;

Abstract: Objective To investigate the association between CHI3L1 polymorphism and asthma in the Han population of Guangdong,and to explore the clinical values of chitinase-like protein YKL-40 in evaluating disease severity and monitoring the progression of the disease.Methods Total 251 objects were divided into asthma group（n=150）and control group（n=101）.The single nucleotide polymorphism（SNP）at CHI3L1 gene was detected with Massarray method.The serum YKL-40 levels,total IgE levels,peripheral blood eosinophil percentage（Eos%）of the objects in asthma and control groups were detected.The asthma patients were divied into asthma exacergation group and stable group,and the serum YKL-40 levels were compared.Results The distribution of A/G at rs3806448 of CHI3L1had significant difference between asthma and control groups（P＜0.01）,and the frequency of A allele at rs3806448 of the patients in asthma group was significantly higher than that in control group（OR=1.93,95% CI=1.30-2.62,χ2=11.6,P＜0.01）.The serum YKL-40 levels,total IgE and Eos% of the patients with AA at rs3806448 were higher than those of the patients with GG or AG at rs3806448（P＜0.05）;the FEV1%of the patients with AA was lower than those of the patients with GG or AG at rs3806448（P＜0.01）.The serum YKL-40 level of the patients in asthma group was significantly higher than that in normal control group（P＜0.01）,and the serum YKL-40 level of the patients in asthma exacergation group was higher than those in asthma stable group and normal control group（P＜0.01）.The serum YKL-40 level of the patients in asthma group was positively correlated with the peripheral blood Eos%and total IgE level（rEos=0.348,rIgE=0.437,P＜0.01）,and was negatively correlated with the lung function（r=-0.745,P＜0.01）.Conclusion The polymorphism of CHI3L1-rs3806448 may correlate with asthma of Han population in Guangdong area.The serum YKL-40 may be a new biomarker to evaluate asthma disease severity and helpful for monitoring illness stage.
Keywords：

bronchial asthma; single nucleotide polymorphism; chitotriosidase 3-like 1;

  • DOI：

    10.13481/j.1671-587x.20140529

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  • Classification Code：

    R562.25

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