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Journal of Sichuan University(Medical Science Edition). 2010, (05) Core

Vasodilatory Effects of CNP on Aortic Arteries of RabbitsChinese Full Text

CHEN Li1,LI Qi-yong2,LIAO Shi-ping3,JIANG Rong-jian2,KONG Hong2,LAI Jin-chuan2,CHENG Biao2,SHU Yan2.1.Department of Physiology,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China;2.Department of Cardiology,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People’s Hospital,Chengdu 610072,China;3.Department of Experiments of Functional Science,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China

Abstract: Objective To investigate the mechanism of vasodilatory effects of C-type natriuretic peptide（CNP）.Methods Tension changes in aortic rings of rabbits were recorded with the presence of CNP or C-type natriuretic peptide receptor（NPR-C） agonist（cANF4-23） after pretreatment with epinephrine（NE） or 60 mmol/L KCl.The vasodilatory effects of four types of potassium channel blocker and NPR-C antagonist（cANF4-28） were also tested.Results A maximal vasorelaxant effects of（33.5±5.9）% and（38.4±10.6）% were recorded in the presence of 1 μmol/L CNP and cANF4-23,respectively.cANF4-28 attenuated the action of CNP（（19.8±8.3）%）.The vasorelaxant effects of CNP and cANF4-23 decreased significantly after pretreatment with 60 mmol/L KCl（P＜0.01）.Glibenclamide and BaCl2 also attenuated the relaxant activities of CNP（P＜0.05）.But only BaCl2 decreased the vasodilatory action of cANF4-23（P＜0.05）.Conclusion The relaxant activity of CNP is mediated through three paths: NPR-B/KATP,NPR-C/KIR and NPR-C/calcium channels.
Keywords：

C-type natriuretic peptide Aortic ring C-type natriuretic peptide receptor Potassium channel;

  • DOI：

    10.13464/j.scuxbyxb.2010.05.046

  • Series：

  • Subject：

  • Classification Code：

    R965.2

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