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Chinese Journal of Antibiotics. 2011, (07) Core

Improved progress of 4-（4-methoxybenzyloxy）-phenylmalonic acid-4-methoxybenzyl mono-esterChinese Full Text

Liu Xiang-kui,Hu Zhi and Yuan Zhe-dong(Shanghai Institute of Pharmaceutical Industry,State Key Laboratory of New Drug and Pharmaceutical Processes,Shanghai 200437)

Abstract: Objective To improve the process of 4-（4-methoxybenzyloxy）-phenylmalonic acid-4-methoxybenzyl mono-ester.Methods 4-（4-methoxybenzyloxy）-phenylmalonic acid-4-methoxybenzyl mono-ester was synthesized from the main material 4-methoxybenzyl chloride and 4-hydroxyphenylacetic acid by esterification,etherification and carboxylation.Results The structure of final product was confirmed by 1H-NMR.Conclusion compared with original process,the improved process reduces the amount of sodium iodide and improves the utilization of solvent with high yield,low cost and easy operation.
Keywords：

Latamoxef disodium; Intermediate; Synthesis;

  • DOI：

    10.13461/j.cnki.cja.004816

  • Series：

  • Subject：

  • Classification Code：

    TQ245.24

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