Recent progress in the study of Hsp90 inhibitorsChinese Full Text
Meng Shuai,Shan Guang-zhi and Li Zhuo-rong(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Beijing 10050)
Abstract: Heat shock protein 90（Hsp90） is a highly conserved chaperone that is responsible for the maturation and activity of a variety of signaling proteins.Hsp90 has become the target of antitumor drugs because of its close relationship with occurrence and development,biological behavior and prognosis of tumor.Many Hsp90 inhibitors have emerged,and interests have arisen around structure-based design of small molecules.In this review,we illustrate the structure features and related inhibitors aiming at discovering and optimizing Hsp90 inhibitors.
- DOI：
10.13461/j.cnki.cja.004774
- Series：
- Subject：
- Classification Code：
R96
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