Shanghai Journal of Acupuncture and Moxibustion. 2014, (10)

Effect of Electroacupuncture at Point Fenglong on the Expressions of Peritoneal Macrophage CD11b and ICAM-1 in Hyperlipidemia RatsChinese Full Text

WANG Qiong;TIAN Jia-yu;XIAO Ying;ZHANG Hong-xing;Wuhan Hospital of Traditional Chinese and Western Medicine;

Abstract: Objective To investigate the effect of electroacupuncture at point Fenglong（ST40） on the expressions of macrophage surface antigen CD11 b and intercellular adhesion molecule-1（ICAM-1） in hyperlipidemia rats. Method Forty healthy SD rats were randomly allocated to normal control, high fat diet, high fat+common diet, high fat diet and treatment, and high fat+common diet and treatment groups. After 28 days of treatment with electroacupuncture at point Fenglong, blood lipid levels, namely, total cholesterol（TC）, triglyceride（TG）, low density lipoprotein cholesterol（LDL-C） and high density lipoprotein cholesterol（HDL-C） contents were measured in every group of rats. The expressions of peritoneal macrophage surface antigen CD11 b and ICAM-1 were examined using flow cytometry（FCM） in every group of rats. Result Plasma TC and LDL-C increased significantly in the high fat diet group of rats compared with the normal control group（P＜0.01）. In the high fat+common diet group of rats, serum TC and LDL-C decreased significantly in comparison with the high fat diet group（P＜0.01） but increased significantly in comparison with the normal control group（P＜0.01）. After treatment with electroacupuncture at point Fenglong, rat plasma TC and LDL-C decreased significantly（P＜0.01） and TG and HDL-C did not change significantly（P＞0.05）. The expression rates of macrophage CD11 b and ICAM-1 increased significantly in the high fat diet group of rats compared with the normal group（P＜0.01）. In the high fat+common diet group of rats, the expression rates of macrophage CD11 b and ICAM-1 decreased significantly in comparison with the high fat diet group（P＜0.05） but increased significantly in comparison with the normal group（P＜0.01）. The expression rates of CD11 b and ICAM-1 decreased significantly in the high fat diet and treatment group compared with the high fat diet group（P＜0.01） and decreased significantly in the high fat+common diet and treatment group compared with the high fat+common diet group（P＜0.01） and the high fat diet and treatment group（P＜0.01）. Correlation analysis showed that CD11 b and ICAM-1 levels had a significantly positive correlation（r=0.947, P＜0.01）. Conclusion Electroacupuncture at point Fenglong can significantly down-regulate blood fat TC and LDL-C levels and the expressions of macrophage CD11 b and ICAM-1 in hyperlipidemia rats. It has a certain therapeutic effect on hyperlipidemia.

Keywords：

Hyperlipidemia; Electroacupuncture; Point,Fenglong; Macrophage; CD11b; ICAM-1; Rats;

DOI：
10.13460/j.issn.1005-0957.2014.10.0951
Series：
Subject：
Classification Code：
R245

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Effect of Electroacupuncture at Point Fenglong on the Expressions of Peritoneal Macrophage CD11b and ICAM-1 in Hyperlipidemia RatsChinese Full Text

WANG Qiong;TIAN Jia-yu;XIAO Ying;ZHANG Hong-xing;Wuhan Hospital of Traditional Chinese and Western Medicine;

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