Impact of Electroacupuncture on the Quantity-effect Relationship of the Action of Intervention in Rabbit Experimental Peripheral Facial ParalysisChinese Full Text
WEI Yan;KOU Jie-you;Heilongjiang University of Traditional Chinese Medicine Second Hospital;
Abstract: Objective To seek the optimum protocol for electroacupuncture treatment of peripheral facial paralysis by analyzing the quantity-effect relationships of the actions of interventions of various factors in the therapeutic effect and provide a scientific experimental basis for an improvement in the clinical therapeutic effect on this disease. Method Fifty-four Japanese white rabbits, half male and half female, were selected. An animal model of left facial nerve injury was made by a nerve entrapment method. An orthogonal experimental design with a combination of three factors（acupuncture time, electroacupuncture waveform and point combination） and three levels（acute, quiescent and convalescent stages; dense, sparse and sparse-dense waves; facial+scalp, facial+body and facial+scalp-body points） was used. The 54 rabbits were randomly allocated to nine groups arranged according to the L9（34） orthogonal table（6 rabbits each）. The experimental observation lasted a total of 4 weeks. Facial motor nerve conduction velocity（MCV） was measured by electrophysiologic study. Result The treatment of experimental peripheral facial paralysis at its acute stage with sparse-dense wave electroacupuncture at facial+body points restored MCV most rapidly. The influences of various factors on the therapeutic effect, ranked in descending order were acupuncture time＞electroacupuncture waveform＞point combination. Conclusion Different factors have different influences on the therapeutic effect of electroacupuncture on rabbit experimental peripheral facial paralysis. Of them, the correct selection of acupuncture time is the main factor producing the effect, electroacupuncture waveform is next and point combination ranks third. The optimum protocol for electroacupuncture treatment of rabbit experimental peripheral facial paralysis is sparse-dense wave electroacupuncture at facial+body points during the acute stage.
Keywords：
Electroacupuncture; Facial paralysis; Orthogonal experimental design; Motor nerve conduction velocity;
- DOI：
10.13460/j.issn.1005-0957.2014.06.0589
- Series：
- Subject：
- Classification Code：
R246
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