Myocardial Protection of Dunhuang Guben Recipe and Its Impact on Related Enzyme Activity of Femoral Quadriceps in Exercise Load RatsChinese Full Text
LI Xibin;PENG Xuejing;PENG Zhihui;
Abstract: Objective: To explore the effect of Dunhuang Guben recipe on related enzyme activity of femoral quadriceps and myocardial protection in exercise load rats. Methods:After adaptive feeding for one week,sixty clean rats were randomly divided into exercise load group and non-exercise load group,thirty in each group. The non-exercise load group was then randomized into two subgroups,blank-non-exercise subgroup and drug-non-exercise subgroup,fifteen in each subgroup. The exercise load group was also randomized into two subgroups,blank-exercise subgroup and drug-exercise subgroup,fifteen in each subgroup. After marked by picric acid,rats in the two drug subgroups were orally administered Dunhuang Guben recipe,and rats in the two blank subgroups were given injection of 0.9% NaCl solution,once a day from the first day to the eighth week. All rats in the exercise load group were treated by progressive load swimming training,from the first day to the eighth week. On the 8th week,all rats were sacrificed,and myocardial tissue and femoral quadriceps were sampled for the detection of physiobiochemic indexes by colorimetry. Results:The difference of succinodehydrogenase（SDH） between blank-non-exercise subgroup and drug-exercise subgroup was significant（P ＜ 0.05）,and the difference between drug-non-exercise subgroup and blank-non-exercise subgroup was markedly significant（P ＜ 0.01）. Significant differences of malate dehydrogenase（MDH）,lactic dehydrogenase（LDH）,and malondialdehyde（MDA）,LD,superoxide dismutase（SOD） were also found between drug-non-exercise subgroup and drug-exercise subgroup（P ＜ 0.05）. Conclusion:Dunhuang Guben recipe can significantly improve hypoxic-ischemic state of cardiac muscle and skeleton muscle caused by exercise load.
- DOI：
10.13457/j.cnki.jncm.2014.04.078
- Series：
- Subject：
- Classification Code：
R285.5
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