Clinical characteristics of oxaliplatin-induced hypersensitivity reactionsChinese Full Text
Du Chun-xia;Hong Ruo-xi;Chen Zhe;Department of Internal Medicine,Cancer Hospital,Chinese Academy of Medical Sciences;Department of Pharmacy,Cancer Hospital,Chinese Academy of Medical Sciences;
Abstract: Objective To explore the incidence and clinical characteristics of oxaliplatin（ LOHP）-induced hypersensitivity reactions（ HRs） in Chinese patients. Methods Clinical information of all patients treated with L-OHP at least once between March 2008 and December 2012 was collected. Detail data from patients who experienced HRs were analyzed. Results Among 194 patients receiving L-OHP-based chemotherapy,21（ 10. 8%） experienced HRs. Grade 3 /4 events occurred in 4. 6%. HRs occurred most frequently in cycle 7-8th（ incidence 7. 3%）. The most common symptom of HRs was delayed pyrexia. The fastest and severest HRs were observed in those manifesting mainly with respiratory or cardiac symptoms. Conclusions The reaearch data shows the incidence of HRs to L-OHP in Chinese patients is similar to that in western population and other eastern Asian populations. Precautions are recommended for first10 minutes since onset of infusion and cycle 7-8th,given the most serious events and the peak of incidence observed during this period.
- DOI：
10.13455/j.cnki.cjcor.2014.02.21
- Series：
- Subject：
- Classification Code：
R730.5
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