Journal of Qinghai Medical College. 2013, (02)

CHANGES OF SERUM ANGPTL3 IN PATIENT WITH TYPE 2 DIABETESChinese Full Text

Qi Hongying1,Zhang Huili2,Gao Jidong2(1.Qinghai University Medical College;2.Qinghai University Affiliated Hospital)

Abstract: Objective To investigate the serum level of angiopoietin-like protein 3（ANGPTL3）in patients with type 2 diabetes mellitus（T2DM）and the influencing factors for it.Methods Fifty five patients with T2DM were selected from the Qinghai university affiliated hospital in June 2012 to November 2012 as the case group,25 non-diabetic volunteers in the healthy center at the same period as the control group.ELISA was used to determine the concentration of serum ANGPTL3 and then compared and analyzed.Results 1.The fasting blood glucose（FBG）,blood urea nitrogen（BUN）and serum ANGPTL3 level of T2DM were higher than those of control group;high-density lipoprotein（HDL）,albumin(ALB,platelet count（PLC）,White blood cell count（WBC）and aspartate aminotransferase（AST）were lower than those of control group;the differences had statistical significance（P＜0.001）,2.Correlation analysis showed that the serum level of ANGPTL3 was negatively correlated with HDL and albumin（ALB）（r:﹣0.384、P＜0.01;r:-0.220;P＜0.05）;and was positively correlated with FPG,urine glucose and BUN（r:0.452,P＜0.01;r:0.317,P＜0.01;r:0.381、P＜0.01）.3.Multivariate stepwise regression analysis showed that FPG,HDL and BUN were the main affecting factors for the serum ANGPTL3;FPG,non-alcoholic fatty liver disease（NAFLD）and blood serum uric acid（BUA）were the main affecting factors for the level of serum ANGPTL3 in patients with T2DM.Conclusion The level of serum ANGPTL3 is significantly higher in patients with type 2 diabetes mellitus than the control group and it shows a close relationship with metabolism changes of glucose and lipid.It indicated that ANGPTL3 may play an important role in the pathological course of T2DM.

Keywords：

ANGPTL3 Type 2 diabetic relationship;

DOI：
10.13452/j.cnki.jqmc.2013.02.011
Series：
Subject：
Classification Code：
R587.1

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CHANGES OF SERUM ANGPTL3 IN PATIENT WITH TYPE 2 DIABETESChinese Full Text

Qi Hongying1,Zhang Huili2,Gao Jidong2(1.Qinghai University Medical College;2.Qinghai University Affiliated Hospital)

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