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Journal of Clinical Radiology. 2012, (05) Core

The Experiment Study of MRI R2* Value for Noninvasive Measurement of Liver Iron Content in Iron Overload RabbitChinese Full Text

HU Su,HU Chunhong,ZHANG Jinggang,et al. Imaging Center,The First Affiliated Hospital of Suzhou University,Suzhou,Jiangsu Province 215006,P.R.China

Abstract: Objective To study the feasibility of MRI R2* for measurement of liver iron content（LIC） in iron overload rabbit compared with the pathological findings and laboratory data,and explore the relationship between R2 * and LIC.Materials and Methods32 adult healthy New Zealand rabbits were randomly divided into four groups,group A（n=8）,group B（n=8）,group C（n=8） and control group（n=8）.Three iron overload groups received intravenous injection of iron sucrose of different dose every one week for four weeks.All experimental animals underwent liver scan with 2D MFGRE sequence by using GE Signa HDx 3.0 T MR.The R2* value were measured on R2* Map with small region of interest（ROI） methods by one observer who had been trained to use the technology proficiently.The liver of experimental animals were sent for LIC assessment immediately after MR scan.SPSS 13.0 for Windows statistical software was used to compare the relationship between R2* value with small ROI methods and LIC.Results（1）The LIC increased with the increased in total dose of iron.（2）There was a significant exponent curve association between the R2* value and LIC.Curve regression equation of the R2* value and LIC was Y=EXP（1.950+ 16.200X）,R=0.894.A weak correlation（R=0.186） was displayed in animals with high LIC（above 20.0 mg/g dw）.ConclusionR2* value can accurately predict LIC with a significant exponent curve association,the correlation become weak with increased LIC（above 20.0 mg/g dw）.
Keywords：

R2* value Magnetic resonance imaging Liver Iron overload;

  • DOI：

    10.13437/j.cnki.jcr.2012.05.017

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  • Classification Code：

    R445.2

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