Journal of Clinical Radiology. 2010, (04) Core

Effect of Transcatheter Arterial Renal Embolization Combined with Cryoablation on Immunological Function of Patients with Advanced Renal CarcinomaChinese Full Text

LIU Changfu,GUO Zhi,XING Wenge,et al.Department of Interventional Therapy,Cancer Institute and Hospital of Tianjin Medical University,Tianjin 300060,P.R.China

Abstract: Objective To analyze the effect of transcatheter renal arterial embolization（TRAE） combined with Argon-Helium cryosurgery （AHCS） on the differentiation of regulatory CD4+ CD25+T cell （Treg） and its implication in patients with advanced renal carcinoma.Materials and Methods Peripheral venous blood samples were obtained from 44 patients with advanced renal carcinoma before and after TRAE combined with AHCS at 1months to 6 months. The percentage of Treg cells and T lymphocyte subsets （CD3+T,CD4+T,CD8+T,CD4+T/CD8+T,and NK cells） in the peripheral blood was measured by flow cytometry. The necrosis of tumor was observed by enhancement CT,MRI,PET-CT 1 months after TRAE combined with AHCS.Results After TRAE combined with AHCS,The percentages of Treg cells were decreased （P＜0.01）.the percentages of CD3+T,CD4+T,NK and CD4+T/CD8+T were significantly increased after TRAE combined with AHCS （P＜0.01）,and the percentage of CD8+T cells was significantly decreased （P＜0.01）.Correlation analysis showed that the decrease of tumor load was positively correlated with the decrease of the percentage of Treg cells （r=0.994,P＜0.01）.Conclusion After TRAE combined with AHCS,the abnormal distribution of subsets of T-lymphocytes can be improved. The percentage of Treg cells is correlated with tumor load.

Keywords：

Renal carcinoma Argon-helium cryosurgery Embolism regulatory T lymphocytes;

DOI：
10.13437/j.cnki.jcr.2010.04.032
Series：
Subject：
Classification Code：
R737.11

Mobile Reading

Read on your phone instantly

Step 1
Scan QR Codes

"Mobile CNKI-CNKI Express" App

Step 2
Open“CNKI Express”

and click the scan icon in the upper left corner of the homepage.

Step 3
Scan QR Codes

Read this article on your phone.
HTML
CAJ Download
PDF Download

Contents

Effect of Transcatheter Arterial Renal Embolization Combined with Cryoablation on Immunological Function of Patients with Advanced Renal CarcinomaChinese Full Text

LIU Changfu,GUO Zhi,XING Wenge,et al.Department of Interventional Therapy,Cancer Institute and Hospital of Tianjin Medical University,Tianjin 300060,P.R.China

Read on your phone instantly

Citation Network

Related Literature