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Protective effect of curcumin solid dispersion on reproductive organ injury induced by cadmium in male ratsChinese Full Text

ZHANG Yu-xin;LI Lin-yu;ZHANG Zhen-zhen;ZHAO Li-gang;DONG Hong-hong;ZHAO Lin-lin;School of Pharmacy,North China University of Science and Technology;

Abstract: Objective To investigate the protective effect of curcumin solid dispersion(Cur SD) on reproductive organ injury in male rats exposed to cadmium.Methods A total of 40 SPF male SD rats were selected and divided into 5 groups:blank group,cadmium exposed group,Cur SD low-dose group,Cur SD medium-dose group and Cur SD high-dose group(n=8,each).Except that the blank group was injected with normal saline(2 mg/kg,ip),the other groups were intraperitoneally injected with 2 mg/kg CdCl2,once every other day for 6 times.Cur SD low-,medium-and high-dose groups were given Cur SD of 30 mg/kg,60 mg/kg and 90 mg/kg respectively,once a day for 6 weeks.The rats in blank group and cadmium exposed group were intragastrically administered with 1% sodium carboxymethyl cellulose solution,once a day for 6 weeks.At the end of the experiment,the rats were killed,the testis and epididymis were removed,the organ coefficient and sperm number were calculated,the activities of SOD,MDA,caspase-3,the content of cadmium in testicular tissue were measured,and the pathological changes of testicular tissue were observed by electron microscope.Results Cadmium reduced the organ coefficient,sperm number and motility rate of rats,after administration of Cur SD high dose increased the organ coefficient,sperm number and activity rate of testis and epididymis.The values of SOD,MDA and caspase-3 were(2.569±0.279) U/mgprot,(18.880±2.942) nmol/mgprot and(1.553 ±0.439) U/mgprot in testicular tissue of cadmium exposed group,and(3.948±0.449) U/mgprot,(4.200±0.762) nmol/mgprot and(0.559±0.167) U/mgprot respectively.After cadmium exposure,cadmium accumulated in testis and epididymis,which decreased SOD activity and increased MDA content(P<0.05),and increased caspase-3 content(P<0.05).After administration,SOD activity increased,MDA content decreased,caspase-3 content decreased.The results showed that the effect of high-dose SD group was the best,the testis atrophy,seminiferous tubule damage and spermatogenic cells decreased in cadmium exposed group,while the Cur SD high-dose group was close to the normal group.Conclusion Cur SD high-dose group can reduce the damage of reproductive organs induced by cadmium in male rats,and has obvious protective effect,which may be related to the concentration of curcumin.
  • DOI:

    10.13429/j.cnki.cjcr.2020.12.002

  • Series:

    (E) Medicine & Public Health

  • Subject:

    Traditional Chinese Medicinal Herbs

  • Classification Code:

    R285.5

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