Preparation and Quality Evaluation of Emodin-loaded Soluplus Polymeric MicellesChinese Full Text
DIAN Ling-hui;YU En-jiang;CHENG Ji-lun;GUO Xiang-hua;HUANG Zi-rong;ZHANG Zhen-sheng;School of Pharmaceutical Sciences,Guangdong Medical College;
Abstract: Objective: To prepare emodin-loaded soluplus polymeric micelles（ Emo-PMs） and evaluate their quality. Method: Emo-PMs were prepared by film dispersion method using an amphiphilic copolymer soluplus. Emo-PMs were characterized by particle size analyzer,transmission electron microscopy（ TEM）,X-ray diffraction（ XRD）; release curve was determined by dynamic membrane dialysis; HPLC was employed to determine entrapment efficiency and drug loading with mobile phase of methanol-0. 1% phosphoric acid（ 75∶ 25）and detection wavelength ar 437 nm. Result: Emo-PMs showed spherical with a mean particle size of（ 65 ± 3. 8）nm,polydispersity index of 0. 099 ± 0. 022, Zeta potential of-（ 12. 7 ± 0. 19） mV, average encapsulation efficiency of（ 88. 25 ± 3. 51） % and average drug loading of（ 4. 51 ± 0. 72） %. Emodin entrapped in polymer micelles with amorphous or molecular form; release methanism of Emo-PMs fitted Higuchi equation. Conclusion:These prepared Emo-PMs had exhibited in vitro sustained release,their particle size,encapsulation efficiency and drug loading were controllable.
Keywords：
emodin; soluplus; polymeric micelles; quality evaluation; cumulative release; drug loading; encapsulation efficiency;
- DOI：
10.13422/j.cnki.syfjx.2014160015
- Series：
- Subject：
- Classification Code：
R283.6
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