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Pharmacology and Clinics of Chinese Materia Medica. 2014, (05) Core

The neuroprotective effect of total coumarine of Angelica pubescentis on APP/PS1 double transgenic AD model mouseChinese Full Text

Jiao Yanan;Hu Yu;Zhao Dan;Sun Dong;Hao Haiguang;Yang Jingxian;Liaoning University of Traditional Chinese Medicine;

Abstract: Objective: To investigate whether total coumarine of Angelica pubescentis（ TCA） exert neuroprotective effect on APP / PS1 double transgenic mice. Methods: 7-month old APP / PS1 mice were randomly divided into model group,TCA low,medium,high dose groups（ 3. 6,7. 2,14. 4 mg / kg）（ n = 10）,with age-matched C57 BL /6J mice of the same genetic background as normal control group. Immunohistochemical fluorescence,HE and Nissl staining as well as Hoechst 33258 staining were used in the present study. Results: In TCA high dose（ 14.4 mg / kg） mice,the pyramidal cells in CA3 zone were significantly improved（ 77. 56 ± 5. 82 n / mm2,P ＜ 0. 01 vs. model group） and Nissl body quantity were increased. In addition,the fluorescence intensity of NF-M was rescued（ 83. 25 ± 10. 74%,P ＜ 0. 01 vs. model group）and the percentage of apoptosis cells was decreased（ 14. 08 ± 3. 27 %,P ＜ 0. 01 vs. model group） in TCA high dose（ 14. 4 mg / kg） group.Conclusion: TCA（ 14. 4 mg / kg） was effective dose,which can significantly protect APP / PS1 mice from neural damage probably through improving NF-M expression and reducing the apoptosis cells in the brain of APP / PS1 transgenic mouse.
Keywords：

total coumarine of Angelica pubescentis（独活香豆素,TCA）; APP / PS1 double transgenic mice; neuroprotective; anti-apoptosis;

  • DOI：

    10.13412/j.cnki.zyyl.2014.05.022

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  • Classification Code：

    R285

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