Proteomic analysis of Danzhixiaoyao Powder on prevention of polycystic ovary syndrome in ratsChinese Full Text
Zhang Lihua1,2,Jing Linlin1,2,Huang Huang1,2,Sun Xuegang 1,2,Liu Ying 3(1 Integrative Hospital,2 School of Traditional Chinese Medicine of Southern Medical University;3 Guangdong General Hospital)
Abstract: Objective: To identify the underlying mechanisms in the protective effects of Danzhixiaoyao Powder（DZXYP） on polycystic ovary syndrome rat model.Methods: PCOS was introduced by subcutaneous implantation of 18-methyl norethisterone silica gel stick combined with subcutaneous injection of human chorionic gonadotrophin.Two-dimensional polyacrylamide gel electrophoresis（2-DE） and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry（MALDI-TOF MS） were used to identify differentially expressed proteins.Immunohistochemistry,real time quantitative polymerase chain reaction（RQ-PCR） and western blot were performed to verify the results above.Results: DZXYP ameliorated ovary enlargement and follicle dilatation.Among eitht successfully identified proteins that were differentially expressed,β-arrestin 2（β-arr2） was upregulated in DZXYP pretreated PCOS group when compared with PCOS group.Conclusion: DXR could alleviate PCOS which might be related to increased expression of β-arr2.
- DOI：
10.13412/j.cnki.zyyl.2013.01.045
- Series：
- Subject：
- Classification Code：
R285
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