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Pharmacology and Clinics of Chinese Materia Medica. 2013, (01) Core

Effects of magnolol and honokiol on short-circuit current of rat ileumChinese Full Text

Zhang Zhibo1,2,Geng Meimei2,Tan Zhiliang2,Deng Yanli1,Xiao Wenjun1,Han Xuefeng2(1 National Research Center of Engineering ＆Technology for Utilization of Functional Ingredients from Botanicals of Hunan Agricultural University,Changsha 410128;2 Institute of Subtropical Agriculture of Chinese academy of Sciences,Changsha 410125)

Abstract: Objective: To study the effects magnolol and honokiol on the electrophysiological parameters of rat ileum.Methods: Ussing chamber system were used to evaluate the effects of 50 μmol/L,100 μmol/L,and 200 μmol/L magnolol or honokiol on ileal short-circuit current.Results: Magnolol and honokiol significantly inhibited the short-circuit current of the rat ileum,and the short-circuit current showed a magnolol or honokiol concentration-dependent reduction.The inhibitory effect of magnolol and honokiol on the short-circuit current was significantly higher（P＜0.01） than that of the calcium channel blocker-verapamil.In addition,pretreatment in Ussing chamber with magnolol or honkiol significantly reduced（P ＜ 0.01） the increase of short-circuit current induced by 10 μmol/L acetylcholine.Conclusion: The short-circuit current of magnolol and honokiol inhibited the short-circuit current of rat ileum and their mechanism of action may be as a calcium antagonist to inhibit the transport of calcium or other ions through intestinal calcium channel regulation.
Keywords：

magnolol（厚朴酚）; honokiol（和厚朴酚）; ileum; short circuit current; ussing chamber;

  • DOI：

    10.13412/j.cnki.zyyl.2013.01.018

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  • Classification Code：

    R285

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