Study on the synergistic effects and decreasing toxicity of Compound Wuguteng Capsule on S180 tumor-bearing mice by the irradiation of 60Coγ rayChinese Full Text
Zhang Xiaoshuang1,Song Yanping2,Zhang Enhu1 (1 Shaanxi University of Chinese Medicine,Xianyang 712046;2 Shaanxi Provincial Academy of Traditional Chinese Medicine,Xi’an 710003)
Abstract: Objective : To study the effect of synergistic effects and decreasing toxicity of Compound Wuguteng Capsule on S180 tumor-bearing mice by the irradiation of 60Coγ ray.Methods: Seventy two mice were randomly divided into six groups,tumor-bearing control group,tumor-bearing+60Coγ radiation group,tumor-bearing+60Coγ radiation+zhenqifuzheng particle group,tumor-bearing+60Coγ radiation+Compound wuguteng capsule large,medium and small dose groups.The models of S180 tumor bearing mice were established.Eccept tumor-bearing control group,the mice of the rest groups were for 60Coγ irradiation for six days,after irradiation it started to give medicine,once a day,for nine days,the next day after the last time given medicine,to observe the weight,tumor weight,spleen index,colony forming unit-spleen（CFU-S）,blood routine,bone marrow nucleated cells.Results: Tumor-bearing+60Coγ radiation+Compound Wuguteng Capsule large dose group obviously inhibit the tumor weight,significantly increase bone marrow nucleated cells,CFU-S and reticulocyte;tumor-bearing+60Coγ radiation+Compound Wuguteng Capsule medium dose group can inhibit the tumor weight,increase reticulocyte and CFU-S;tumor-bearing+60Coγ radiation+Compoundwuguteng capsule small dose group can inhibit the tumor weight.Conclusion: Compound wuguteng capsule have synergistic effects and decreasing toxicity on S180 tumor-bearing mice by the irradiation of 60Coγ ray.
Keywords：
Compound Wuguteng Capsule（复方乌骨藤胶囊）; 60Coγ ray; tumor-bearing mice; synergistic effect; decreasing toxicity;
- DOI：
10.13412/j.cnki.zyyl.2012.03.057
- Series：
- Subject：
- Classification Code：
R285
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