The influence of chronic cerebral hypoperfusion on cognitive function in rats of DihuangyinziChinese Full Text
Zhang Xiaoshuang,Bai Liming (Shaanxi University of Chinese Medicine,Xianyang 712046)
Abstract: Objective:To observe the influence and mechanism of chronic cerebral hypoperfusion on cognitive function in rats of Dihuangyinzi.Method:Using rat model of chronic cerebral hypoperfusion by two-vessel occlusion,Learning and memory improvement was measured by Morris water maze,and T-AOC content was measured in hippocampu.Apoptotic cells rate in the hippocampus was measured by Flow cytometry.Result:Dihuangyinzi 20g/kg、10g/kg group,escape latency shortened,the number of cross platform increased,T-AOC content in the hippocampus was increased,Apoptosis in the hippocampus was significantly lower in rats.Conclusion:Dihuangyinzi improve the cognitive function of chronic cerebral hypoperfusion rats,which may be antioxidant and protection of hippocampal neurons,inhibit brain cell apoptosis.
- DOI：
10.13412/j.cnki.zyyl.2011.02.001
- Series：
- Subject：
- Classification Code：
R285
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