Analysis of histopathology and prognosis of retinoblastoma after enucleationChinese Full Text
LUO Xin;YE Hui-Jing;DING Yun-Gang;DU Yi;YANG Hua-Sheng;the Zhongshan Ophthalmic Center,Sun Yat-Sen University;Department of Ophthalmology,Affiliated Hospital of Zunyi Medical College;
Abstract: Objective To analyze the relationship between eyeball invasive locations and prognosis of retinoblastoma for metastasis after enucleation,and offer a reliable guide to adjuvant therapy. Methods Retrospective study was done about patients with unilateral retinoblastoma treated by enucleation without prior treatment at Zhongshan Ophthalmic Center of Sun Yat-Sen University between January 2003 and February 2011. The locations of tumor invasion,treatment and survival condition of patients were recorded,and the 5-PEFS（ 5 year probability event-free survival） was calculated. Follow-up visit ended until patients died or by February 2012. The followup period was（ 46. 3 ± 29. 2） months. Results A total of 202 eyes of 202 patients were enrolled in this study. The patients with the laminar or prelaminar involvement accounted for the largest proportion（ 40. 6%）,which had the highest 5-PEFS（ 96. 1%）. The 5-PEFS of the patients with post-laminar optic nerve involvement and transection line of optic nerve involvement were 82. 5% and 40. 0%,respectively. The patients with post-laminar optic nerve involvement accepted adjuvant chemotherapy had a tendency of higher 5-PEFS（ 91. 6%） than that of untreated patients（ 66. 7%,P = 0. 09）. The 5-PEFS of patients accepted treatment with transection line of optic nerve involvement significant higher than that of untreated patients（ P ＜ 0. 01）. The 5-PEFS of patients with isolated choroid invasion was 93. 8%. The 5-PEFS of patients with tumor invasion to sclera who received adjuvant chemotherapy and that of those did not receive adjuvant chemotherapy were respectively 77. 8% and 57. 1%（ P ＞ 0. 05）. Two patients with orbit invaded died. Four of 202 patients recurrented in orbit after enucleation. The average time from enucleation to relapse was 9. 8 months（ 5- 15 months）. Conclusion Histopathology after enucleation may provide a reference to prognosis and adjuvant therapy. Almost all recurrences of retinoblastoma occur within2 years,especially 1 year,after enucleation,during which all retinoblastoma patients have to keeping close follow-up.
- DOI：
10.13389/j.cnki.rao.2014.0318
- Series：
- Subject：
- Classification Code：
R739.7
- Mobile Reading
Read on your phone instantly
Step 1Scan QR Codes
"Mobile CNKI-CNKI Express" App
Step 2Open“CNKI Express”
and click the scan icon in the upper left corner of the homepage.
Step 3
Scan QR Codes
Read this article on your phone.
- HTML
- CAJ Download
- PDF Download
Download the mobile appuse the app to scan this coderead the article.
Tips: Please download CAJViewer to view CAJ format full text.
Download: 311 Page: 1147-1151 Pagecount: 5 Size: 150K
Citation Network
Related Literature
- Similar Article
- Reader Recommendation
- Associated Author