Antibacterial activity of the extracts of Amorpha fruticosa seedsChinese Full Text
LI Qian;HUANG Shan-shan;YUAN Ru-qiang;DIAO Yun-peng;ZHANG Bao-jing;ZHEN Yu-hong;ZHANG Hou-li;Department of Pharmacy,Dalian Medical University;
Abstract: Objective To measure the antibacterial activity of extracts of Amorpha fruticosa seeds.Methods The ethanol extracts of Amorpha fruticosa seeds were extracted with petroleum ether,ethyl acetate and n-butanol,respectively.Staphylococcus aureus and Klebsiella pneumoniae were selected as the tested bacteria.The minimum inhibitory concentration（MIC） and the minimum bactericidal concentration（MBC） were determined by tube double dilution method;time-kill curve was determined by spread plate method;bacterial ultrastructure was observed by using electron microscopy.Results The antibacterial activity of the ethanol extract of Amorpha fruticosa seeds treated with ethyl acetate was stronger against the tested bacteria,with the MIC and MBC against Staphylococcus aureus were respectively 2.5 mg / mL and 5.0 mg / mL,while the MIC and MBC to Klebsiella pneumoniae were 5.0 mg / mL and 10.0 mg / mL respectively.Time kill curves showed that the inhibiton of the extracts against bacteria was concentration-and time-dependent.Electron microscope results suggested that the drug effect may be related to the destruction of bacterial cell wall and changes of cell membrane permeability.Conclusion The extracts of Amorpha fruticosa seeds have obvious antibacterial effects.
- DOI：
10.13381/j.cnki.cjm.201403008
- Series：
- Subject：
- Classification Code：
R284
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