The role of Pdx1 in pancreas development and diabetesChinese Full TextEnglish Full Text (MT)
YAN Cheng-Zhi;Key Laboratory of Southwest China Wildlife Resource Conservation of the Ministry of Education,College of Life Science, China West Normal University;
Abstract: Pdx1(pancreatic and duodenal homeobox 1) is one of the homeodomain transcription factors, and it is essential in pancreas development and islet β-cell function. It has been reported that homozygous deficiency of Pdx1 in mice leads to pancreatic agenesis. Pdx1 can also regulate β-cell maturation and differentiation by cooperating with other factors or cis-acting. In addition, Pdx1 increases insulin secretion through directly binding to and activating insulin promoter. In recent studies, Pdx1 is proved to play an important role in generation of β-like cells, gene editing and drug development. Therefore, this article mainly reviews the role and molecular mechanisms of Pdx1 in pancreas development and diabetes.
Keywords:
- DOI:
10.13376/j.cbls/2019144
- Series:
(A) Mathematics/ Physics/ Mechanics/ Astronomy; (E) Medicine & Public Health
- Subject:
Endocrine and Systemic Disease
- Classification Code:
R587.1
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