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SCREENING FOR AND IDENTIFICATION OF TISSUE-SPECIFIC MARKERS OF SALIVARY ADENOID CYSTIC CARCINOMAChinese Full Text

WANG Sainan;REN Hao;SUN Yinyin;LI Xin;LIU Siyu;XU Xiaoyu;LU Shulai;Deparment of Stomatology, Binzhou People’s Hospital;

Abstract: Objective To identify specific markers in cancer tissue samples from patients with salivary adenoid cystic carcinoma(SACC) using proteomics methods, and to find potential specific markers for the diagnosis of SACC. Methods Two-dimensional difference gel electrophoresis(2 D DIGE) was used to detect differentially expressed protein spots between SACC tissue and adjacent normal parotid gland tissue in four cases of SACC, and mass spectrometry was used to identify the proteins with good reproducibility. Results A total of 39 differentially expressed protein spots between SACC tissue and normal parotid gland tissue were detected by 2 D DIGE. The paired t-test(Average ratio ≥1.5,P<0.05) was performed on these differentially expressed protein spots to find 24 spots with up-regulated expression and 15 spots with down-regulated expression. Five proteins, namely α-amylase 1, glucose regulated protein(GRP), protein disulfide isomerase(PDI), LASP1 protein, and PFN1 protein, were identified by mass spectrometry analysis of the differentially expressed protein spots with good reproducibility. Conclusion α-Amylase 1, GRP, PDI, LASP1 protein, and PFN1 protein may be potential tissue-specific biomarkers for early diagnosis of SACC.
  • DOI:

    10.13362/j.jpmed.202006005

  • Series:

    (E) Medicine & Public Health

  • Subject:

    Oncology; Stomatology

  • Classification Code:

    R739.87;R730.43

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