EFFECTS OF ACUTE GLUCOSE LOADING ON INFLAMMATION AND OXIDATIVE STRESS IN PATIENTS WITH SIMPLE HYPERLIPIDEMIAChinese Full Text

CHU Xia,LIU Li-yan,SUN Chang-hao(Department of Nutrition and Food Hygiene,Public Health College,Harbin Medical University,Harbin 150081,China)

Abstract: Objective To study the changes in inflammatory factors and markers of oxidative stress after acute glucose loading in patients with simple hyperlipidemia.Method Fifty-five patients with simple hyperlipidemia（HLP group） and 54 healthy persons（Con group） were investigated.All subjects underwent oral glucose tolerance test（OGTT）.Serum inflammatory factors including C-reactive protein（CRP）,tumour necrosis factor-alpha（TNF-α）,interleukin-6（IL-6）,and markers of oxidative stress including malondialdehyde（MDA）,superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px） were determined at fasting state and OGTT-2 h.Results At fasting state and OGTT-2 h,serum levels of CRP,TNF-α,IL-6 and MDA were increased,and serum levels of SOD and GSH-Px were decreased in HLP group（P＜0.001 or P＜0.05）,as compared with Con group,respectively.For HLP subjects,serum levels of CRP,TNF-α and IL-6 at OGTT-2 h were increased（P＜0.05）,and serum levels of SOD and GSH-Px were decreased（P＜0.001,P＜0.05）,as compared with fasting state.For healthy control subjects,serum level of IL-6 at OGTT-2 h was increased（P＜0.05）,and levels of MDA,SOD and GSH-Px were decreased（P＜0.001,P＜0.05）,as compared with fasting state.Conclusion The inflammatory reaction and oxidative stress in patients with simple hyperlipidemia are further aggravated by acute glucose loading,which may play a important role in development of chronic diseases（such as atherosclerosis） caused by hyperlipidemia.

Keywords：

hyperlipidemia; acute glucose loading; inflammation; oxidative stress;

DOI：
10.13325/j.cnki.acta.nutr.sin.2012.05.021
Series：
Subject：
Classification Code：
R589.2

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EFFECTS OF ACUTE GLUCOSE LOADING ON INFLAMMATION AND OXIDATIVE STRESS IN PATIENTS WITH SIMPLE HYPERLIPIDEMIAChinese Full Text

CHU Xia,LIU Li-yan,SUN Chang-hao(Department of Nutrition and Food Hygiene,Public Health College,Harbin Medical University,Harbin 150081,China)

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