Expression of Wnt-1 and β-catenin in cervical squamous cell carcinomas and relationship with metastasisChinese Full Text
CHEN Ai-rong;ZHAO Wei-dong;WU Shi-wu;CHENG Ze-nong;Department of Obstetrics and Gynecology,Anhui Provinical Hospital,Anhui Medical University;Department of Obstetrics and Gynecology,Jieshou People’s Hospital;Department of Pathology,Bengbu Medical College;
Abstract: Purpose To investigate the expression of Wnt-1 and β-catenin protein in cervical squamous cell carcinomas（ CSCC） and their relationship with invasion and lymph node metastasis. Methods Expression of Wnt-1 and β-catenin protein were examined on immunohistochemistry containing 78 specimens of CSCC and 30 specimens of normal cervical tissues. Results The positive rates of Wnt-1 and β-catenin protein in normal cervical tissues were 20. 0% and 10. 0% respectively. The positive rates of Wnt-1 and β-catenin protein in CSCC were 56. 4%,and 74. 4% respectively. There was a significant difference between the two groups（ P ＜ 0. 001）.The positive rates of Wnt-1 and β-catenin protein in 33 cases with lymph node metastasis of CSCC were 72. 7% and 90. 9% respectively. The positive rates of Wnt-1 and β-catenin protein in 45 cases with no lymph node metastasis of CSCC were 44. 4% and 62. 2% respectively. The expression of Wnt-1 and β-catenin protein was significantly related with grades of tumors and depth of invasion and FIGO stages（ P ＜ 0. 05）,and there was no significantly difference between the expression of Wnt-1 and β-catenin protein and CSCC patients age（ P ＞ 0. 05）. Spearman analysis showed that the expression of Wnt-1 protein was positive related to the expression of β-catenin protein（ rs= 0. 490,P ＜ 0. 001）. Conclusion The abnormal expression of Wnt-1 and β-catenin may be involved in initiation,development,invasion,and metastasis of CSCC,and it is suggested that Wnt-1 and β-catenin be considered as potential markers for invasion,metastasis,and prognosis.
- DOI：
10.13315/j.cnki.cjcep.2014.09.008
- Series：
- Subject：
- Classification Code：
R737.33
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