Advances in protective role of Nrf2/ARE during pathogenic infectionChinese Full Text
OU Guang-li;ZHU Cui-ming;Institute of Pathogenic Biology,University of South China;
Abstract: Nuclear transcription factor E2-related factor 2（ Nrf2） is a key regulator in antioxidant defense response in host cells. Nrf2 shares in common a cis-acting enhancer sequence termed antioxidant response element（ ARE） that includes antioxidant enzymes and phase Ⅱ detoxifying enzyme,which play an important role in cell protection. Oxidative stress is an important part of the pathogenic infection. Pathogen infection can activate Nrf2 / ARE signaling pathways to develop the product directly or by inducing host cells for reactive oxygen species（ ROS）,leading to a increasing expression of protective protein and protect the host cell from oxidative damage. The expression of Nrf2 has a cruicial relationship with pathogen infection,this article will review the Nrf2 / ARE pathways in the latest research of anti-pathogen infection.
Keywords：
- DOI：
10.13309/j.cnki.pmi.2014.01.013
- Series：
- Subject：
- Classification Code：
R392
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