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Chinese Journal of Hospital Pharmacy. 2014, (18) Core

Analgesic effect of dezocine in elderly patients with vertebroplastyChinese Full Text

ZHENG Xin-hua;DUAN Hai-ping;HA Si-yuan;YUAN Guang-chao;Department of Anesthesiology,Wuhan City Hospital of TCM;

Abstract: OBJECTIVE To observe the clinical analgesic effect of dezocine in elderly patients with vertebroplasty.METHODS 120 cases of ASA involvedⅠ-Ⅲgrade,were randomly divided into three groups using a random number table:Group A,B and C.40 patients were in each group.Intravenous injection of 0.1 mg·kg-1 dezocine was used in Group A,intravenous injection of 1μg·kg-1 fentanyl was adopted in group B,and group C was a control group.Changes of MAP,HR,SPO2 index,adverse reactions and pain score（VAS）were recorded respectively before administration（T1）,at time of operation start（T2）,filling bone cement（T3）,and at the end of operation（T4）.RESULTS HR,MAP in group A and group B was significantly lower than that in group C at T2,T3,T4（P＜0.05）,VAS score in group A at T2,T3,T4 were significantly lower than that in group B and group C（P＜0.05）,while that of group B at T2,T3 was lower than in the group C（P＜0.05）.The adverse reaction of group A was 12.5%,in group B was 35%,and there was statistically significant difference between the two groups（P＜0.05）.CONCLUSION Dezocine used in vertebroplasty keeps hemodynamic stability;it has satisfactory analgesic effect and fewer incidences of adverse reactions.
Keywords：

dezocine; fentanyl; elderly patients; vertebroplasty; analgesia;

  • DOI：

    10.13286/j.cnki.chinhosppharmacyj.2014.18.20

  • Series：

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  • Classification Code：

    R614

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