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Chinese Journal of Virology. 2014, (06) Core

Molecular Epidemiology of HFMD-associated Pathogen Coxsackievirus A6 in Fujian Province,2011-2013Chinese Full Text

CHEN Wei;WENG Yu-wei;HE Wen-xiang;ZHANG Yong-jun;YANG Xiu-hui;Huang Meng;XIE Jian-feng;WANG Jin-zhang;ZHENG Kui-cheng;YAN Yan-sheng;Fujian Center for Disease Control and Prevention;

Abstract: In order to characterize the molecular epidemiology of HFMD-associated Coxsackievirus A6（CVA6）in Fujian Province,a total of 1340 specimens from non-EV71non-CVA16 HFMD patients were collected during 2011-2013.Isolated virus strains were identified and subtyped.Full-length coding regions for the VP1 gene of the predominant serotype CVA6 isolates were amplified and sequenced.Among the375non-EV71 non-CVA16 HFMD cases confirmed by virus isolation and molecular subtyping,182（48.5%）were found to be caused by CVA6,accounting for 7.9%,16.2% and 39.6% HFMD-associated enteroviruses in FujianProvince during 2011,2012,and 2013,respectively.Compared with general features observed in the HFMD epidemic,no difference in CVA6-specificity or severity rates was observed between geographical origins,gender,or age groups.Nucleotide sequence analyses of VP1 genes revealed high diversity levels of 16.2%-18.6%among CVA6 strains from Fujian Province,in contrast to the prototype CVA6 strain,and showed low levels of diversity in the amino acid sequences（4.3%-6.2%）.Phylogenetic analysis also indicated that CVA6 isolates from Fujian Province were distinct from the prototype strain and other isolates from abroad;however,it was homologous to domestic strains,although the Fujian isolates clustered into multiple branches.These results suggested that significant changes in the pathogenic spectrum of HFMD in Fujian Province occurred during 2011-2013,as CVA6 was one of the predominant serotypes of HFMD.CVA6 isolates from Fujian Province were co-circulating and co-evolving with other domestic strains as multiple closely related CVA6 transmission chains were observed in Fujian Province overall and within each prefecture.
Keywords：

Hand,foot and mouth disease（HFMD）; Coxsackievirus A6（CVA6）; Molecular epidemiology;

  • DOI：

    10.13242/j.cnki.bingduxuebao.002575

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  • Subject：

  • Classification Code：

    R373

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