The Effects of Caffeic Acid on the Growth of Transplanted Tumors of Esophageal Squamous Cell Carcinoma KYSE450 in Nude Mice and Its Molecular MechanismChinese Full Text
JIN Hao;LI Fu-zhi;ZHANG Qiang;WU Bin;SONG Xiao-bo;Department of Cardiothoracic Surgery, Fourth Clinical Hospital of Jinzhou Medical University (Panjin Liaoyou Baoshihua Hospital);Department of Thoracic Surgery, Third Affiliated Hospital of Jinzhou Medical University;
Abstract: Objective: To explore and study the effects of caffeic acid on the growth of esophageal squamous cell carcinoma KYSE450 transplanted tumors in nude mice and its molecular mechanism. Methods: Nude mice with transplanted esophageal squamous cell carcinoma(n=48) were randomly divided into three groups-model group, 5-fluorouracil group and caffeic acid group. The three groups were injected intraperitoneally with 0.2 m L saline, 5-fluorouracil 25 g/kg, 5-fluorouracil 25g/kg and caffeic acid 50 mg/kg, twice a week for 4 weeks. Results: The body weight of the 5-fluorouracil group and the caffeic acid group were higher than that of the model group in the 2nd and 4th weeks of treatment(P<0.05), and the caffeic acid group were higher than that of the 5-fluorouracil group(P<0.05). The tumor volume in the 5-fluorouracil group and the caffeic acid group at the 2nd and 4th weeks of treatment were less than that of the model group(P<0.05), and the caffeic acid group were higher than that in the 5-fluorouracil group(P<0.05). The levels of serum TNF-α and IL-6 in the 5-fluorouracil group and caffeic acid group were lower than those in the model group(P<0.05), and the caffeic acid group were lower than that in the 5-fluorouracil group(P<0.05) at the 4th weeks of treatment. The relative expression levels of Bax and Caspase-3 protein and apoptosis index of xenograft tumors in the 5-fluorouracil group and caffeic acid group were higher than the model group(P<0.05), and the caffeic acid group were higher than that of the 5-fluorouracil group at the 4th weeks of treatment(P<0.05).Conclusion: The application of caffeic acid in nude mice with esophageal squamous cell carcinoma can play a synergistic effect with5-fluorouracil. It can promote the apoptosis of transplanted tumor cells, inhibit the expression of inflammatory factors, and reduce the total number of blood vessels by up-regulating the expression of Bax and Caspase-3 proteins. Thereby inhibiting the growth of transplanted tumors, and promoting the restoration of nude mice body weight.
Keywords:
Caffeic acid; Esophageal squamous cell carcinoma; Nude mice; Transplanted tumor; Apoptosis; 5-fluorouracil; Inflammatory factor;
- DOI:
10.13241/j.cnki.pmb.2022.06.007
- Series:
(E) Medicine & Public Health
- Subject:
Oncology
- Classification Code:
R735.1
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