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Progress in Modern Biomedicine. 2014, (06)

The Expression of B7-H1 on Dendritic Cell and its Effects on Immune Functions in Patients with Different HBV DNA LoadsChinese Full Text

WANG Yun;LI Hong-xia;FENG Tao;WANG Yuan-yuan;BAI Lu;SONG Bo;MEI Xia-qi;Department of Infectious disease of The Fourth Affiliated Hospital of Harbin Medical University;

Abstract: Objective: To observe the expression of B7-H1 on dendritic cell and its effects on immune functions in patients with chronic hepatitis B. Methods: 60 patients with chronic hepatitis B were enrolled and divided into three groups according to the level of HBV-DNA and ALT. Twenty healthy people were enrolled and served as controls. The expressions of CD80, CD83, CD86, HLA-DR, CD1a and B7-H1 on myeloid dendritic cells（mDC） in the peripheral blood were analyzed by flow cytometry. The level of IL-10, IL-12 in the supernatants of mixed lymphocytes reaction were detected by enzyme linked immunosorbent assay（ELISA）. T-test was used for the statistical analysis. Results: The expressions of CD80, CD83, CD86, HLA-DR, CD1a on mDC in CHB patients were significantly lower than those in healthy controls and the B7-H1 expression on mDC were higher than controls. The differences were significant（P＜0.05）. The expression level of B7-H1 was positively correlated with ALT level. Conclusions: The expression of B7-H1 on mDC in CHB patients is higher than those of healthy people and results in immune suppression. It may be one of the reasons for chronic HBV infection.
Keywords：

Chronic hepatitis B; Myeloid dendritic cells（mDC）; B7-H1; IL-12; Immune functions;

  • DOI：

    10.13241/j.cnki.pmb.2014.06.008

  • Series：

  • Subject：

  • Classification Code：

    R512.62

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