Research Progress on Cytokeratin 20 in Bladder CancerChinese Full Text
ZHANG Ming-ming;XIU You-cheng;Urinary surgery of the First Affiliated Hospital of Harbin Medical University;
Abstract: Bladder tumors were the most common tumors of the urinary system,accounting for more than 95% of epithelial tumors,the vast majority were urinary tract transitional cell carcinoma.The early symptoms of bladder cancer were unobvious,and the recurrence rate was high,early diagnosis and treatment were very important to improve its efficacy.In recent years,new diagnosis of bladder cancer was emerging,significantly improved the diagnosis and prognosis prediction level of bladder tumor.Markers detection of bladder tumor had become a new method for the diagnosis of bladder tumors,which had important clinical significance.It was found that cytokeratin 20（CK20） was one of the members of the family of intermediate filaments,which specifically expressed in umbrella cells of normal bladder tissue as well as bladder transitional cell carcinoma.It had high specificity and sensitivity of diagnosis of bladder cancer,and was closely related to the clinical grade,pathologic stage and metastasis of bladder tumor.So it could be used as a marker for the diagnosis and prediction of prognosis of bladder tumor.This article summarized the research progress on cytokeratin 20 in bladder cancer.
- DOI：
10.13241/j.cnki.pmb.2014.01.052
- Series：
- Subject：
- Classification Code：
R737.14
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