Adenosine A2A receptor and nervous system diseasesChinese Full Text
WANG Mei-liang;YU Gang;SU Rui-bin;College of Pharmaceutical Sciences, Guangxi Medical University;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences;
Abstract: Adenosine, which arises from the breakdown of adenosine triphosphate, is extensively distributed in mammalian tissues and cells. Adenosine exerts its regulating effects on cell function via binding to the specific membrane receptors. Adenosine receptors are belong to G-protein-coupled receptors and can be subdivided into A1, A2A, A2Band A3receptors in mammals. Among these receptors,A2Ahas been demonstrated to be related to pathogenesis of many diseases. In the present review, we focus on the recent progress made in investigating the relationship between A2Aand nervous system disorders, which may provide new strategies for treatment of these diseases.
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- DOI：
10.13220/j.cnki.jipr.2014.03.005
- Series：
- Subject：
- Classification Code：
R964
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