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China Surfactant Detergent ＆ Cosmetics. 2014, (09) Core

Synthesis of 6,7-dimethoxycoumarinChinese Full Text

LIU Xian-ming;TANG Xiao fang;Department of Chemical Engineering,Taizhou Institute of Science and Technology,NJUST;

Abstract: First intermediate,4,5-dimethoxysalicylaldehyde was synthesized by demethylation of 2,4,5-trimethoxybenzaldehyde with boron tribromide. The yield is about 64%. Then second intermediate4,5-dimethoxy-2-hydroxy ethyl phenylacrylate was prepared from the first intermediate by reaction with ethyl malonate and the yield is about 79%. Finally the targeted product 6,7-dimethoxycoumarin was synthesized from the second intermediate via cyclization with thionyl chloride and yield is about 51%. All the intermediates and product were characterized by1 HNMR and MS. The results showed that the targeted intermediates and product were prepared as required.
Keywords：

fragrance; 6,7-dimethoxycoumarin; demethylation; condensation; cyclization;

  • DOI：

    10.13218/j.cnki.csdc.2014.09.116

  • Series：

  • Subject：

  • Classification Code：

    TQ245.24

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