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Journal of Clinical Cardiology. 2014, (07) Core

Association between PAI-1 activity and its polymorphism in Uygur patients with venous thromboembolism of XinjiangChinese Full Text

Gulinigeer WUBULI;Ailiman MAHEMUTI;Gulimire TUNIYAZI;XIA Yuning;HU Xuemei;ZHANG Yunjiao;Heart Center,First Affiliated Hospital,Xinjiang Medical University;

Abstract: Objective:To investigate the association between single nucleotide insertion/deletion（4G/5G）polymorphism of PAI-1gene and venous thromboembolism（VTE）.Method:The 198 cases including 86 Uygur and112Han ethnic diagnosed with VTE by the First Affiliated Hospital of Xinjiang Medical University between January 2008 to June 2011 were admitted in this study.And 212 population including 92 Uygur ethnic and Han 120 ethnic were studied as controls.PCR-RFLP was applied to detect the polymorphism of PAI-1gene 4G/5Gpolymorphism in the promoter region.Result:The PAI-1gene 4G/5Gpolymorphism distribution in Uygur VTE patients and control groups were:4G/4G（81.4%vs.66.3%）,4G/5G（15.1%vs.21.7%）and 5G/5G（3.5%vs.12%）,respectively;and in Han VTE patients and control groups were:4G/4G（67.9% vs.51.7%）,4G/5G（19.6%vs.29.2%）and 5G/5G（12.5%vs.19.2%）,respectively,and there were significant differences in distribution of PAI-1 4G/5Gpolymorphism between VTE patients and controls（P＜0.05）.Besides,plasma PAI-1activity in PAI-1gene 4G/4Ggenotype were statistically higher than 4G/5Gand 5G/5Ggenotype（P＜0.05）.Multifactor logistic regression analysis showed that,PAI-1gene 4G/4Ggenotype（OR=1.914,95%CI3.345~5.708,P=0.001）and plasma PAI-1activity（OR=2.167,95%CI1.489~3.153,P=0.000）were independent risk factors for Uygur patients while smoking（OR=2.867,95%CI1.062~6.586,P=0.024）and plasma PAI-1activity（OR=1.357,95%CI1.141~1.614,P=0.001）were independent risk factors for Han VTE patients.Conclusion:The plasma PAI-1activity was higher in VTE patients compared to normal population in both Uygur and Han ethnic group,and plasma PAI-1activity was an independent risk factor for VTE patients in Uygur and Han ethnics.The frequency of PAI-1gene 4G/4Ggenotype was higher in VTE population than normal population,and 4G/4Ggenotype is an independent risk factor for Uygur VTE patients.
Keywords：

plasminogen activator inhibitor-1; gene polymorphism; venous thromboembolism; Uyghur;

  • DOI：

    10.13201/j.issn.1001-1439.2014.07.007

  • Series：

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  • Classification Code：

    R543.6

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