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Chinese Journal of Biologicals. 2013, (09)

Effect of time after vaccination and varicella attack rate on effectiveness of a single dose of varicella vaccineChinese Full Text

WU Li-ping;LIU Gang;ZHANG Hong;XIA Jun;XIE Ting;SONG Mu-jun;LIANG Jian-hua;Tianhe District Center for Disease Control and Prevention;

Abstract: Objective To investigate the effect of time after vaccination and varicella attack rate on the effectiveness of a single dose of varicella vaccine.Methods A case-control study with 1 ∶ 1 matching was performed in patients at ages of 1 15 years,who occurred in January to June 2011 in Tianhe District,Guangzhou City,China,to evaluate the effect of time after vaccination and varicella attack rate on the effectiveness of a single dose of varicella vaccine.Results A total of 601 pairs of patients / normal controls were investigated.The total effectiveness of vaccine was 70.33%（95% CI: 60.42% 77.76%,P ＜ 0.01）.The effectiveness of vaccine was 90%（95% CI: 65.27% 97.12%,P ＜ 0.01）in the children at ages of one year,and showed a decreasing tendency with increasing age（χ2 trend = 12.68,P ＜ 0.01）.The varicella attack rates showed no significant difference in the patients / normal controls at ages of not less than 10 years,indicating basic disappearance of protective effect of vaccine.In the 511 pairs of patients / normal controls at ages of 2 15 years in cluster case study,the effectiveness of varicella vaccine was 66.67%（95% CI: 54.52% 75.57%,P ＜ 0.01）,and decreased with the increasing attack rate,which showed no significant difference in patients and in normal controls when the attach rate was more than 15%（P ＞ 0.05）,indicating basic disappearance of protective effect of vaccine.Conclusion The failure rate of vaccination with a single dose of varicella vaccine was about 10%.Both the time after vaccination and varicella attack rate showed significant effect on the effectiveness of varicella vaccine,while the latter was more likely.It was suggested that a booster dose of varicella vaccine should be given to control the outbreak of varicella in children.
Keywords：

Live attenuated varicella vaccine; Vaccine effectiveness; Case-control study;

  • DOI：

    10.13200/j.cnki.cjb.000144

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  • Classification Code：

    R392

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