Journal of Liaoning University of Traditional Chinese Medicine. 2013, (02)

Effect of Wenshenfang on Myocardial Tissue Structure and Pathological Changes of Experimental Subclinical Hypothyroidism RatsChinese Full Text

YANG Ruixia1,CHEN Ruquan2(1.Xuchang Hospital of Traditional Chinese Medicine of Henan Province,Xuchang 461000,Henan,China;2.Hubei University of Chinese Medicine,Wuhan 430060,Hubei,China)

Abstract: Objective:This topic,based on the old theory of traditional Chinese medicine and professor CHEN’s clinical experience,was to observe the myocardial tissue pathological changes of SCH by experimental SCH rats.Methods:48 experimental SCH Wistar rats,made by resected thyroid tissue and replaced therapy of L-T4,were divided into 6 groups:the blank control group,the model group,the group treated by low-dose Wenshenfang everyday,the group treated by high-dose Wenshenfang everyday,the group treated by L-T4 everyday and the group treated by L-T4 and Wenshenfang everyday.The cardiomyocyte apoptosis and the pathomorphological changes of heart were researched.The effects on the index of Wenshenfang were observed as well.Results:It was found that compared with the blank control group,the content of myocardial hydroxyproline and collagen reduced（P＜0.01）;the group treated by L-T4 and Wenshenfang everyday and the group treated by high-dose Wenshenfang everyday had raised（P＜0.01）compared with the model group,and the content of the group treated by high-dose Wenshenfang everyday was approximately the same as that of the blank control group（P＞0.05）.The rats’ myocardial tissue after HE-stained was enlarged 400 times through microscope,we inspected that the cells of the group treated by L-T4 everyday,the group treated by L-T4 and Wenshenfang everyday and the group treated by high-dose Wenshenfang everyday were approximately the same as that of the blank control group.We also inspected that the model group rats cardiac tissue muscle nuclei was irregular.The myocardial tissues of rats in the group treated by L-T4 everyday,the group treated by L-T4 and Wenshenfang everyday and the group treated by high-dose Wenshenfang everyday were with irregular nuclei,perinuclear space locally increasing,cytokinesis in myofibrillar arranging well,obvious sarcomere,mitochondria swollen,sarcoplasmic reticulum mild dilatation.Conclusion:The present experiments indicate that SCH is associated with the variation of the content of myocardial collagen,structure and function of myocardium in rats.Wenshenfang could reverse these changes to a certain degree.This topic is expected to afford the theory evidence for treating SCH and advance the theory of treating SCH by warming Yang and tonifying kidney therapy.

Keywords：

subclinical hypothyroidism; thyroid function; myocardial collagen; light microscope; transmission electron microscope; Wenshenfang;

DOI：
10.13194/j.jlunivtcm.2013.02.47.yangrx.084
Series：
Subject：
Classification Code：
R581.2

Mobile Reading

Read on your phone instantly

Step 1
Scan QR Codes

"Mobile CNKI-CNKI Express" App

Step 2
Open“CNKI Express”

and click the scan icon in the upper left corner of the homepage.

Step 3
Scan QR Codes

Read this article on your phone.
HTML
CAJ Download
PDF Download

Contents

Effect of Wenshenfang on Myocardial Tissue Structure and Pathological Changes of Experimental Subclinical Hypothyroidism RatsChinese Full Text

YANG Ruixia1,CHEN Ruquan2(1.Xuchang Hospital of Traditional Chinese Medicine of Henan Province,Xuchang 461000,Henan,China;2.Hubei University of Chinese Medicine,Wuhan 430060,Hubei,China)

Read on your phone instantly

Citation Network

Related Literature