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Chinese Archives of Traditional Chinese Medicine. 2011, (07)

The influence of Tongfu Decoction on CGRP in Acute Lung Injury Rats ModelChinese Full Text

LIU Jian-qiu,WANG Xue-hui,LI Zhu-ying(Pneumology Department,1st Affiliated Hospital of Heilongjiang Chinese Medicine University,Harbin 150040,Heilongjiang,China)

Abstract: Objective:To observe the effect on CGRP in ALI rat lung tissue,and to approach the mechanism of Tongfu Decoction anti-ALI.Method:180 Wistar rats were divided into 6 groups randomly:the normal control group,the model group,hexadecadrol group,Chinese herbal medicine low-dose group,medium-dose group,and high-dose group,30 rats each group.Copying ALI model by caudal vein injecting LPS,giving respectively the Chinese herbal medicine intragastric administration and Dexamethasone intraperitoneal injection half an hour later,and executing rats in 1,2,6 hour after treatment respectively,10 rats each time in each group.We detected CGRP contene in lung by ELISA method.Results:CGRP contents in the model group were higher than the normal control group（P＜0.05）;contents in hexadecadrol group and Chinese herbal medicine groups were lower than the model group（P＜0.05）;contents in Chinese herbal medicine low-dose group were higher than hexadecadrol group（P＜0.05）;Chinese herbal medicine medium-dose group、high-dose group and hexadecadrol group had no statistical significance（P＞0.05）;contents in Chinese herbal medicine medium-dose group and high-dose group showed lower than low-dose group（P＜0.05）;Chinese herbal medicine medium-dose group and high-dose group had no statistical significance（P＞0.05）.Conclusions:Tongfu Decoction could decrease CGRP in lung of ALI rats,medium-dose and high-dose group were better.
Keywords：

Tongfu Decoction; ALI; TGF-β1;

  • DOI：

    10.13193/j.archtcm.2011.07.24.liujq.068

  • Series：

  • Subject：

  • Classification Code：

    R285.5

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