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Liaoning Journal of Traditional Chinese Medicine. 2012, (11)

Observation of Clinical Effect of Xuanfu Daizhe Decoction on Treating Diabetic Gastroparesis Due to the Weakness of Spleen and StomachChinese Full Text

LI Guo-yong1,JIA Rui-xin1,HOU Chao1,LI Yu-hua1,ZHANG Ju-mei1,LU Xiu-qin2(1.Internist Department of Zhaoxian Chinese Medicine Hospital,Zhaoxian 051530,Hebei,China; 2.People’s Hospital of Hebei Province,Shijiazhaung 050000,Hebei,China)

Abstract: Objective:To observe and research on the relationship between quantity of Xuanfu Daizhe Decoction and the clinical effect on its function of improving DGP’s gastrointestinal motility.Methods:108 DGPs were randomly divided into treatment group and comparison group with 54 cases in each.Treatment group with more dose（1 Liang equals 15.625g）,comparison group with less dose（1 Liang equals 3g）;both groups adopt oral administration,1 dosage a day for consecutively 4 weeks.The changes of SP and VIP（in plasmas）distribution and changes of electrogastrogram before and after the treatment were detected by IHCA Method.Results:SP and VIP expressions in plasma were decreased obviously（P＜0.01）in the treatment group,electrogastrogram changes before and after the treatment had statistical meaning（P＜0.01）,and the percentage of normal slow waves after meals had statistical meaning（P＜0.05）.Conclusion:The function of Xuanfu Daizhe Decoction on improving gastrointestinal motility may have close relationship with SP and VIP expressions in plasma,and the dose-effect relation is obvious.
Keywords：

diabetic gastroparesis; Xuanfu Daizhe Decoction; SP; VIP; electrogastrogram;

  • DOI：

    10.13192/j.ljtcm.2012.11.126.ligy.039

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  • Classification Code：

    R259

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