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Liaoning Journal of Traditional Chinese Medicine. 2012, (08)

Influence of Dahuang Huanglian Xiexin Decoction or Lizhong Pill on VEGF Contents in Serum and bFGF Contents in Stomach Tissue of Gastric Ulcer Induced by Indomethacin Combined with Cold or Heat SyndromeChinese Full Text

YU Hai1,CHAI Jian-bo2,ZHAO Wei-guo,BI Jun-hui2,JIANG Lei,XIE Tian2,GAO Qing-zhu,LIJi2(1.Changchun University of Traditional Chinese Medicine,Changchun 130117,Jilin,China; 2.Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China)

Abstract: Objective:To evaluate the gastric ulcer induced by abdominal injection of indomethacin combined with cold or heat syndrome from the angle of pharmacodynamics,and to explore the change regularity of cold or heat syndrome,through observing the influence of Dahuang Huanglian Xiexin Decoction or Lizhong Pill on the contents of bFGF and VEGF of this model rats.Methods:Cold or heat factors combined with abdominal injection of indomethacin were used to establish gastric ulcer model.Euzymelinked immunosorbent assay was used to detect the contents of VEGF in serum and the contents of bFGF in stomach.Results:Compared to the blank group,the contents of VEGF in serum and the contents of bFGF in stomach increased remarkably in each model groups（P＜0.05 or P＜0.01）.Dahuang Huanglian Xiexin Decoction or Lizhong Pill can respectively increase the contents of VEGF in serum and bFGF in stomach of heat-ulcer group or cold-ulcer group obviously（P＜0.05 or P＜0.01）.Conclusion:The protection action for stomach mucoca of Dahuang Huanglian Xiexin Decoction on heat-gastric ulcer,or Lizhong Pill on cold-gastric ulcer both can be achieved by increasing the contents of bFGF and VEGF,performing the regulation of formula-syndrome corresponding,and verifying the success gastric ulcer model of duplicating disease-syndrome combination.
Keywords：

gastric ulcer; cold or heat syndrome; VEGF; bFGF;

  • DOI：

    10.13192/j.ljtcm.2012.08.204.yuh.073

  • Series：

  • Subject：

  • Classification Code：

    R285.5

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