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Liaoning Journal of Traditional Chinese Medicine. 2012, (06)

Review of Mechanism Prevention and Treatment of G Protein-Adenylate Cyclase Signal Pathway in Alzheimer’s DiseaseChinese Full Text

LUO Ben-hua1,2,ZHANG Xue-zhu1,ZHAO Lan1,CHENG Hai-yan1,HAN Jing-xian1,YU Jian-chun1(1.Molecular Biology Laboratory,Acupuncture and Moxibustion Research Institute,The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China; 2.Faculty of Zhuang Medicine of Guangxi University of Traditional Chinese Medicine,Nanning 530000,Guangxi,China)

Abstract: In AD,both the abnormal content and the change of distribution of many kinds of signaling molecules and the abnormal signal pathways play very important roles in Alzheimer’s disease pathological change,and the abnormal information transfer and signal pathways are common channel in Alzheimer’s disease pathogenesis.Firstly,the difference of expressed content in Gsα and Giα protein is the important cause of functional disorder of adenylate cyclase signal system.Secondly,the difference of G protein coupled activity can bring about the functional disorder of adenylate cyclase signal system.（1） The coupled disorder between Gsα,Giα protein and adenylate cyclase can cause functional disorder of adenylate cyclase in AD.（2）The disorder of GTPase activity which can hydrolyses Gα-GTP into Gα-GDP is the important cause of signal transduction dysfunction.Thirdly,the receptors coupled G protein activity disorder and receptor desensitization are the important aspects of affecting G protein activity.Fourthly,ability impairment of ligands activating G-protein-coupled receptor can also bring about functional disorder of adenylate cyclase.Finally,the disorder of adenylate cyclase signaling can also cause Alzheimer’s disease pathological change.The disorder of adenylate cyclase signaling mediated by G protein has an important evocation to prevent and treat Alzheimer’s disease.
Keywords：

Alzheimer’s Disease; G Protein-Adenylate Cyclase Signal Pathway; Review of Mechanism;

  • DOI：

    10.13192/j.ljtcm.2012.06.231.luobh.091

  • Series：

  • Subject：

  • Classification Code：

    R749.16

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