Effect of fluvastatin on PAPP-A and ox-LDL levels in patients with coronary heart diseaseChinese Full Text

CAI Gao-jun1,WANG Ling-yan2,HE Guo-ping1,BAI Qing-li1(1.Department of Cardiology,Affiliated Wujin Hospital,Jiangsu University,Changzhou 213000,Jiangsu,China; 2.Department of Cardiology,China-Japan Union Hospital affiliated to Jilin University,Changchun 130031,Jilin,China)

Abstract: AIM To observe the effect of fluvastatin on PAPP-A and ox-LDL levels in patients with coronary heart disease. METHODS Seventy-five patients with coronary heart disease were divided into acute myocardial infarction （n=32）,unstable angina pectoris （n=22） and stable angina pectoris （n=21） groups,and 60 subjects without coronary disease were used as controls. The serum PAPP-A and ox-LDL were detected by ELISA. RESULTS The level of PAPP-A in acute coronary syndrome （ACS,including acute myocardial infarction and unstable angina pectoris） patients was significantly higher than those in stable angina pectoris patients and controls （P＜0.05）. The level of ox-LDL in patients with coronary heart disease was significantly higher than that in controls （P＜0.05）,with significant difference between AMI,UAP and SAP groups （P＜0.05）. After the treatment with fluvastatin,the levels of PAPP-A and ox-LDL markedly decreased （P＜0.01） and the level of PAPP-A was positive correlated with that of ox-LDL （P＜0.01）. CONCLUSION After fluvastatin treatment,the levels of PAPP-A and ox-LDL greatly decrease in coronary heart disease group. Fluvastatin has a protective effect on heart by repressing inflammatory reaction and attenuating oxidative stress.

Keywords：

pregnancy-associated plasma protein-A; oxidized low-density lipoprotein; coronary disease;

DOI：
10.13191/j.chj.2008.06.65.caigj.034
Series：
Subject：
Classification Code：
R541.4

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Effect of fluvastatin on PAPP-A and ox-LDL levels in patients with coronary heart diseaseChinese Full Text

CAI Gao-jun1,WANG Ling-yan2,HE Guo-ping1,BAI Qing-li1(1.Department of Cardiology,Affiliated Wujin Hospital,Jiangsu University,Changzhou 213000,Jiangsu,China; 2.Department of Cardiology,China-Japan Union Hospital affiliated to Jilin University,Changchun 130031,Jilin,China)

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