Effect of angiotensinⅡand benazepril on remodeling of cardiac gap junction connexin43Chinese Full Text

ZHANG Wei-ze1,SHAO Peng2,CHEN Yong-qing1,MA Ling1,LI Fu-jun1,YIN Qiang1(1.Department of Cardiology,General Hospital,Lanzhou Military Area Command,Lanzhou 730050,Gansu,China;2.Department of Cardiology,Second People’s Hospital of Gansu Province,Lanzhou 730000,Gansu,China)

Abstract: AIM To investigate the effect of angiotensinⅡ（AngⅡ）and benazepril on the level and distribution changes of connexin43（Cx43）in rats with suprarenal abdominal aorta banded.METHODS Thirty male Wistar rats were randomly divided into control group（A）,abdominal aorta banded group（B）and abdominal aorta banded plus benazepril group（C）.The plasma and myocardium concentration of AngⅡ was determined by radioimmunoassay after eight weeks.Cx43 was detected with immunohistochemical method and was semi-quantitatively analyzed in different groups.RESULTS The plasma and myocardium concentration of Ang Ⅱ increased markedly（P＜0.01）but the Cx43 protein level of atrial and ventricular tissue in group B decreased significantly（P＜0.05 and P＜0.01,respectively）with misdistribution compared with those in group A.Cx43 level increased significantly（P＜0.01）in group C compared with that in group B and the inhomogeneity in Cx43 distribution decreased.CONCLUSION The results show that Cx43 remodeling with redistribution and reduction of protein expression may be induced by the increase of Ang Ⅱlevel and benazepril attenuates Cx43 remodeling effectively.

Keywords：

angiotensin Ⅱ; gap junction connexin43; benazepril; remodeling;

DOI：
10.13191/j.chj.2008.01.27.zhangwz.007
Series：
Subject：
Classification Code：
R541

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Effect of angiotensinⅡand benazepril on remodeling of cardiac gap junction connexin43Chinese Full Text

ZHANG Wei-ze1,SHAO Peng2,CHEN Yong-qing1,MA Ling1,LI Fu-jun1,YIN Qiang1(1.Department of Cardiology,General Hospital,Lanzhou Military Area Command,Lanzhou 730050,Gansu,China;2.Department of Cardiology,Second People’s Hospital of Gansu Province,Lanzhou 730000,Gansu,China)

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