Sympathetic neural remodeling after myocardial infarction correlates with growth associated protein-43 in rabbitsChinese Full Text

ZHANG Chao,ZHENG Qiang-sun,GAO Yuan,LEI Jing-yi,LIU Wen-xiu,ZHANG Zhong,ZHANG Xian-wei(Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi′an 710038,Shaanxi,China)

Abstract: AIM To explore the expression of growth associated protein-43（GAP-43） and its effect on neural remodeling after myocardial infarction（MI） in rabbits and the effect of β-blocker on neural remodeling.METHODS Samples were obtained from the MI rabbits in peri-infarcted area,ventricular septum and right ventricle（RV）.By immunohistochemistric method and computer image processing technique,the expression of GAP-43 and the density and extent of sympathetic innervation were examined in different groups（3 days,7 days,30 days after MI and propranolol taken orally）.RESULTS In 3 day group,the expressions of GAP-43 were significantly higher in peri-infarcted area and higher in RV and ventricular septum than those in control areas（P＜0.01）,the density of sympathetic nerve decreased in peri-infarcted area and ventricular septum（P＜0.01） and increased in RV significantly（P＜0.01）,and GAP-43 expression correlated with sympathetic innervation in RV（P＜0.05）.In 7 day group,the expressions of GAP-43 and density of sympathetic nerves in peri-infarcted area,ventricular septum and RV significantly increased（P＜0.01）,and GAP-43 expression correlated with sympathetic innervation in peri-infarcted area（P＜0.01）.In 30 day group,the expressions of GAP-43 decreased significantly in peri-infarcted area,ventricular septum and RV（P＜0.01）,and the density and the extent of sympathetic nerve were higher than those in 3 and 7 day groups.Propranolol decreased the density of sympathetic innervation in ventricular septum and RV（P＜0.05） and normalized the extent of sympathetic innervation in the whole ventricle after left ventricular MI.CONCLUSION The expression of GAP-43 in myocardium is dynamic and correlated with the density and extent of sympathetic innervation.β-blocker plays an important role in improving this sympathetic neural remodeling.

Keywords：

myocardial infarction; sympathetic nerve; neural remodeling; growth associated protein-43; β-blocker;

DOI：
10.13191/j.chj.2007.02.28.zhangch.008
Series：
Subject：
Classification Code：
R542.22

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Sympathetic neural remodeling after myocardial infarction correlates with growth associated protein-43 in rabbitsChinese Full Text

ZHANG Chao,ZHENG Qiang-sun,GAO Yuan,LEI Jing-yi,LIU Wen-xiu,ZHANG Zhong,ZHANG Xian-wei(Department of Cardiology,Tangdu Hospital,Fourth Military Medical University,Xi′an 710038,Shaanxi,China)

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