Effect of Staphylococcus aureus on expressions of cell adhesion molecules and inflammatory mediator in left ventricular myocardiumChinese Full Text

ZHAO Bo,SUN Wei,FU Xiang-ning,CHEN Qi-fu(Department of Tharocardiosurgery,Tongji Hospital,Tongji Medical Collage,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

Abstract: AIM To investigate how Staphylococcus aureus influences gene expressions of cell adhesion molecules（E-Selectin,PECAM-1,VCAM-1） and MCSF-1 in left ventricular myocardium and explore the cellular immunology mechanism of infective endocarditis.METHODS Seven rabbits received 5×10⁶ colony forming units Staphylococcus aureus i.v.,9 rabbits underwent mitral surgery and 8 rabbits underwent both interventions in combination.The hearts were explanted 24 h after the intervention and observed by naked eye and electron microscope.mRNA abundance was determined by semiquantitative duplex RT-PCR.Results were compared with those in control group consisting of 7 untreated rabbits.（RESULTS） Whereas the bacteraemia did not lead to upregulated mRNA levels of any studied molecules,mitral valve surgery caused significantly higher relative expression levels of E-Selectin,PECAM-1 and MCSF1,but not of VCAM-1.The combination of bacteremia and mitral valve surgery caused an uneven expression pattern with a significant upregulation of E-Selectin and MCSF-1 and a downregulation of PECAM-1 and VCAM-1.CONCLUSION Staphylococcus aureus leads to changes of regulations of specific cell adhesion molecules and MCSF-1 in left ventricular myocardium after surgical procedure,thus resulting in the development of infective endocarditis.

Keywords：

endocarditis; Staphylococcus aureus; adhesion molecule; inflammatory mediator;

DOI：
10.13191/j.chj.2006.05.16.zhaob.004
Series：
Subject：
Classification Code：
R378

Mobile Reading

Read on your phone instantly

Step 1
Scan QR Codes

"Mobile CNKI-CNKI Express" App

Step 2
Open“CNKI Express”

and click the scan icon in the upper left corner of the homepage.

Step 3
Scan QR Codes

Read this article on your phone.
HTML
CAJ Download
PDF Download

Contents

Effect of Staphylococcus aureus on expressions of cell adhesion molecules and inflammatory mediator in left ventricular myocardiumChinese Full Text

ZHAO Bo,SUN Wei,FU Xiang-ning,CHEN Qi-fu(Department of Tharocardiosurgery,Tongji Hospital,Tongji Medical Collage,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China)

Read on your phone instantly

Citation Network

Related Literature